KMID : 0389420080160020099
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Korean Journal of Stress Research 2008 Volume.16 No. 2 p.99 ~ p.106
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The Antidepressant Effect of Nelumbinis semen on Forced Swimming Test in the Rat
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Lee Kyu-Sop
Bae Hyun-Su Shim In-Sop Kang Moon-Kyu Cho Chong-Woon Kim Kyung-Soo
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Abstract
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Depression is a major mood disorder, characterized by depressed mood, feeling of worthlessness and disturbed appetite. Nelumbinis semen (NS), lotus seed, has been widely used in Korean traditional medicine as a remedy for insomnia, anxiety, and women¡¯s depression following post-menstrual-pause. We recently found NS to have an anti-depressant effect on chronic mild stress-induced depression-like symptom in the rat. The purpose of the present study was to examine the effect of NS extracs on depression-like symptom in the forced swimming test (FST) in the rat, which is widely used as a behavioral screening test for antidepressant activity of new compounds. We prepared five extracts using water, ethyl acetate, n-butyl alcohol, n-hexane and ethanol as solvents. When animals treated with each extract were executed on FST, n-butyl alcohol extract showed the strongest inhibitory effect on the immobility time. We further fractionated n-buthyl alcohol into five feactions with different mixture of water and methanol, and the 3£º7 (water£ºmethanol) fraction was the most effective on the immobility time on FST. In further study, unknown compounds in this fraction and neural mechanisms underlying their anti-depressant actions should be examined.
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KEYWORD
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Nelumbinis semen(NS), Antidepressant, Forced Swimming Test(FST)
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